恶性淋巴瘤患者淋巴结中VTR区域外的罕见HRAS1等位基因。

Rare HRAS1 alleles outside the VTR region in lymph nodes from patients with malignant lymphoma.

作者信息

Stul M, Baens M, Mecucci C, Van den Berghe H, Cassiman J J

机构信息

Center for Human Genetics, University of Leuven, Belgium.

出版信息

Cancer Genet Cytogenet. 1993 Aug;69(1):60-4. doi: 10.1016/0165-4608(93)90115-3.

DOI:10.1016/0165-4608(93)90115-3

PMID:8104094

Abstract

We found a new type of rare HRAS1 alleles arising de novo in the lymph node of lymphoma patients. Rare alleles of 6.2 kb (a0.1) and 7.3 kb (a2.3) are displayed in the presence of common alleles of 6.6 kb (a1) and 7.6 kb (a3), respectively. These rare alleles lack nucleotide sequences, present in the common alleles in the 5' part between the BamHI and XmaIII site. In addition, the rare alleles may have the classic A-G mutation in the intron at position 2719. In contrast to what is observed for rare constitutional alleles, the VTR region of these rare alleles has the same size as the common alleles. At present the significance of this new type of alleles is not clear.

摘要

我们在淋巴瘤患者的淋巴结中发现了一种新的罕见HRAS1等位基因，其为新生型。6.2 kb（a0.1）和7.3 kb（a2.3）的罕见等位基因分别在6.6 kb（a1）和7.6 kb（a3）的常见等位基因存在的情况下显示出来。这些罕见等位基因在BamHI和XmaIII位点之间的5'部分缺乏常见等位基因中存在的核苷酸序列。此外，这些罕见等位基因在内含子的2719位可能存在经典的A-G突变。与罕见的构成性等位基因不同，这些罕见等位基因的VTR区域与常见等位基因大小相同。目前，这种新型等位基因的意义尚不清楚。