Zadionchenko V S, Bagatyrova K M, Stankevich T V
Kardiologiia. 1993;33(3):40-2.
A total of 80 patients aged 34 to 65 years who suffered from stage-II hypertensive disease were followed up. The selective beta-adrenoblocker tenolol was used alone. Platelet hemostasis, cyclic nucleotides, thromboxane-prostacyclin system and blood rheological properties were examined. Tenolol was found to have a pronounced antihypertensive effect in the patients and to be beneficial in correcting impaired blood rheological properties and platelet homeostasis. It is concluded that the baseline blood rheological properties and the status of the hemostatic system largely determine the natural history of hypertension and the efficacy of therapy.
对80例年龄在34至65岁之间患有II期高血压病的患者进行了随访。单独使用选择性β-肾上腺素能阻滞剂心得乐。检测了血小板止血、环核苷酸、血栓素-前列环素系统和血液流变学特性。发现心得乐对患者有显著的降压作用，并且有助于纠正受损的血液流变学特性和血小板内环境稳定。得出的结论是，基线血液流变学特性和止血系统状态在很大程度上决定了高血压的自然病程和治疗效果。
