[Thrombocytic-vascular hemostasis and the rheological properties of the blood during the tenolol treatment of hypertension patients].

A total of 80 patients aged 34 to 65 years who suffered from stage-II hypertensive disease were followed up. The selective beta-adrenoblocker tenolol was used alone. Platelet hemostasis, cyclic nucleotides, thromboxane-prostacyclin system and blood rheological properties were examined. Tenolol was found to have a pronounced antihypertensive effect in the patients and to be beneficial in correcting impaired blood rheological properties and platelet homeostasis. It is concluded that the baseline blood rheological properties and the status of the hemostatic system largely determine the natural history of hypertension and the efficacy of therapy.