Powrie F, Coffman R L
DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304.
Immunol Today. 1993 Jun;14(6):270-4. doi: 10.1016/0167-5699(93)90044-L.
CD4+ T cells, via the cytokines that they produce, play a pivotal role in the induction and regulation of cell-mediated and humoral immunity. Recently it has become clear that the CD4+ T-cell population is heterogeneous and that distinct CD4+ T-cell subsets, defined by their cytokine repertoire, regulate cell-mediated and humoral immune responses. Protective responses to pathogens are dependent on activation of the appropriate TH subset accompanied by its characteristic set of immune effector functions. Evidence to date suggests that the cytokines produced by the TH cells themselves are important regulators of TH subset activation and differentiation. Here, Fiona Powrie and Robert Coffman discuss how manipulation of the levels of these cytokines can be used to alter the balance of TH cell subsets and illustrate some clinical situations where this may be beneficial.
CD4+ T细胞通过其所产生的细胞因子，在细胞介导的免疫和体液免疫的诱导及调节中发挥关键作用。最近已明确，CD4+ T细胞群体是异质性的，并且由其细胞因子谱所定义的不同CD4+ T细胞亚群调节细胞介导的免疫和体液免疫反应。对病原体的保护性反应依赖于适当的TH亚群的激活及其特征性的免疫效应功能。迄今为止的证据表明，TH细胞自身产生的细胞因子是TH亚群激活和分化的重要调节因子。在此，菲奥娜·鲍里和罗伯特·科夫曼讨论了如何通过操纵这些细胞因子的水平来改变TH细胞亚群的平衡，并举例说明了一些可能有益的临床情况。
