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[麦角胺镇痛药滥用所致偏头痛患者的每日慢性头痛:门诊治疗方案的疗效]

[Daily chronic headache in patients with migraine induced by abuse of ergotamine-analgesics: response due to a protocol of outpatient treatment].

作者信息

Pascual J, Berciano J

机构信息

Departamento de Medicina y Psiquiatrìa, Hospital Universitario Marqués Valdecilla, Santander.

出版信息

Neurologia. 1993 Aug-Sep;8(7):212-5.

PMID:8104438
Abstract

Chronic daily headache appears in migraine patients due to chronic consumption of analgesics-ergotamine. This entity was considered intractable without hospital admission. Our aim was to study the response of this headache to an outpatient treatment protocol. The therapeutic protocol included: 1. Oral information to the patient about the role of analgesics in the chronification of the headache; 2. Abrupt withdrawal of analgesics-ergotamine; 3. Administration of naproxen as symptomatic medication, and 4. Prophylactic treatment. After 2.5 months of treatment we evaluated both the frequency and the intensity of pain episodes as well as analgesic consumption. Thirty patients (8.6% of the outpatient consultations) suffered from chronic daily headache secondary to chronic analgesic abuse. Twenty five were females and 5 were males, their mean age +/- SD being 43 +/- 11 years. The mean +/- SD number of units of analgesics-ergotamine taken per week was 28 +/- 12. Three patients exclusively abused analgesics, the remainder either ergotamine, caffeine and various analgesics (18) or caffeine or several analgesics not containing ergotamine (9). In 29 patients the response was positive. Twenty (67%) showed an excellent improvement (> 75%) in frequency and intensity and completely gave up analgesics. The remaining nine (30%) improved moderately (50-75%). Only 3 patients in this group carried on taking analgesics. One patient showed no improvement. Our work confirms the epidemiological magnitude of chronic daily headache and shows that this is a treatable entity on an outpatient basis combining the abrupt withdrawal of analgesics-ergotamine, and their replacement by naproxen, with prophylactic treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

偏头痛患者因长期服用镇痛药麦角胺而出现慢性每日头痛。这种情况在不住院的情况下被认为难以治疗。我们的目的是研究这种头痛对门诊治疗方案的反应。治疗方案包括:1. 向患者口头告知镇痛药在头痛慢性化中的作用;2. 突然停用镇痛药麦角胺;3. 给予萘普生作为对症药物;4. 预防性治疗。治疗2.5个月后,我们评估了疼痛发作的频率和强度以及镇痛药的使用情况。30例患者(占门诊咨询患者的8.6%)因慢性镇痛药滥用而患有慢性每日头痛。25例为女性,5例为男性,他们的平均年龄±标准差为43±11岁。每周服用镇痛药麦角胺的平均单位数±标准差为28±12。3例患者仅滥用镇痛药,其余患者要么滥用麦角胺、咖啡因和各种镇痛药(18例),要么滥用咖啡因或不含麦角胺的几种镇痛药(9例)。29例患者反应良好。20例(67%)在频率和强度上有显著改善(>75%),并完全停用了镇痛药。其余9例(30%)有中度改善(50-75%)。该组中只有3例患者继续服用镇痛药。1例患者无改善。我们的研究证实了慢性每日头痛的流行病学规模,并表明通过突然停用镇痛药麦角胺,并用萘普生替代,同时进行预防性治疗,这种疾病在门诊是可以治疗的。(摘要截取自250字)

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