Armaly M F, Araki M
Invest Ophthalmol. 1975 Oct;14(10):724-31.
Rapid, short-lasting elevation of ocular pressure level produces simultaneous reduction in blood-flow rate in the distal 6 mm. of the extraocular portion of the optic nerve of the rhesus monkey as monitored by the heated thermocouple technique. The magnitude of this reduction was very small until intraocular pressure (IOP) exceeded 50 mm. Hg following which markedly and progressively greater reduction in blood-flow rate occurred at higher IOP levels; maximum reduction was reached at IOP of 105 mm. Hg. The magnitude of reduction in blood-flow rate for each ocular pressure level was significantly greater when systemic arterial pressure was reduced. These effects were monitored 2 to 4 mm. behind the globe and became reduced at a more proximal location, disappearing at locations further than 6 mm. from the globe. The results suggested a reduction in nutrient blood flow to the optic nerve at the monitored site with elevation of IOP.
通过加热热电偶技术监测发现，恒河猴眼内压水平快速、短暂升高会同时导致视神经眼外部分远端6毫米处的血流速度降低。在眼内压（IOP）超过50毫米汞柱之前，这种降低幅度非常小，之后在更高的眼内压水平下，血流速度会显著且逐渐更大幅度地降低；在眼内压为105毫米汞柱时达到最大降低幅度。当体循环动脉压降低时，每个眼内压水平下血流速度的降低幅度显著更大。这些效应在眼球后2至4毫米处监测到，在更近端的位置会减弱，在距离眼球超过6毫米的位置消失。结果表明，随着眼内压升高，监测部位视神经的营养血流减少。
