Roberts J A
Invest Urol. 1975 Sep;13(2):117-20.
Coliforms given intravenously usually fail to produce pyelonephritis unless urinary obstruction or other anatomic abnormalities are present. Previously, we had observed progressive pyelonephritis after hematogenous infection only in monkeys which seemed to have an abnormality of ureteral function. To further test this observation, unilateral ureteral instillation of Escherichia coli 04.06, and 0111 was carried out under base line pressure conditions. Animals infected with E. coli 04 showed unilateral absence of ureteral peristalsis, delay in excretion of radionuclide on scintiphoto studies, and ureteritis histologically. This study confirms that certain strains of E. coli cause ureteral dysfunction. So called nonobstruction pyelonephritis may really be obstructive.
静脉注射大肠埃希菌通常不会引发肾盂肾炎，除非存在尿路梗阻或其他解剖学异常。此前，我们仅在似乎存在输尿管功能异常的猴子身上观察到血源性感染后进展性肾盂肾炎。为进一步验证这一观察结果，在基线压力条件下对单侧输尿管进行大肠杆菌04、06和0111的灌注。感染大肠杆菌04的动物出现单侧输尿管蠕动缺失、放射性核素排泄延迟以及组织学上的输尿管炎。这项研究证实某些大肠杆菌菌株会导致输尿管功能障碍。所谓的非梗阻性肾盂肾炎可能实际上是梗阻性的。
