Sidenberg D G, Bassett A S, Demchyshyn L, Niznik H B, Macciardi F, Kamble A B, Honer W G, Kennedy J L
Section of Neurogenetics, Laboratories of the Clarke Institute of Psychiatry, Toronto, Ont., Canada.
Hum Hered. 1993 Sep-Oct;43(5):315-8. doi: 10.1159/000154150.
A new HincII polymorphism for the human serotonin 1D receptor variant (5-HT1D beta) is reported. In light of evidence indicating possible dysfunction of the 5-HT neurotransmitter system in schizophrenia, this new 5-HT receptor polymorphism was tested for linkage to schizophrenia in 5 Canadian pedigrees. Although 1 of the 5 pedigrees tested had a slightly positive lod score, there was no evidence overall for linkage to schizophrenia under dominant, recessive, or two locus models.
据报道，人类血清素1D受体变体（5-HT1Dβ）出现了一种新的HincII多态性。鉴于有证据表明精神分裂症患者的5-羟色胺神经递质系统可能存在功能障碍，我们在5个加拿大家系中对这种新的5-羟色胺受体多态性与精神分裂症的连锁关系进行了检测。尽管在检测的5个家系中有1个家系的对数优势比分值略呈阳性，但总体而言，在显性、隐性或双基因座模型下，均未发现与精神分裂症存在连锁关系的证据。
