在28个家庭中未能复制5号染色体q11 - q13区域标记与精神分裂症之间的连锁关系。
Failure to replicate linkage between chromosome 5q11-q13 markers and schizophrenia in 28 families.
作者信息
Campion D, d'Amato T, Laklou H, Sabate O, Jay M, Leboyer M, Malafosse A, Gorwood P, Babron M C, Hillaire D
机构信息
Unité de Recherche d'Epidémiologie Génétique (INSERM U 155), Château de Longchamp, Gif sur Yvette, France.
出版信息
Psychiatry Res. 1992 Dec;44(3):171-9. doi: 10.1016/0165-1781(92)90021-t.
Sherrington et al. (1988) reported linkage between markers located on the 5q11-q13 region of chromosome 5 and schizophrenia in five Icelandic and two British families. To date, however, all attempts to replicate the initial finding have failed. Using three markers of chromosome 5, we have studied 28 additional French pedigrees. When our data were analyzed both with parametric (i.e., lod scores) and nonparametric methods, we found no evidence of linkage. Thus, we were unable to replicate the earlier report by Sherrington et al.
谢林顿等人（1988年）报告称，在五个冰岛家庭和两个英国家庭中，位于5号染色体5q11 - q13区域的标记与精神分裂症之间存在连锁关系。然而，迄今为止，所有重复最初发现的尝试均以失败告终。我们使用5号染色体的三个标记，对另外28个法国家系进行了研究。当我们使用参数法（即对数优势分数）和非参数法对数据进行分析时，未发现连锁证据。因此，我们无法重复谢林顿等人早期的报告。
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