CD16+ K细胞与抗体包被的靶标的黏附是由CD2和CD18受体介导的。
Adhesion of CD16+ K cells to antibody-coated targets is mediated by CD2 and CD18 receptors.
作者信息
Voltarelli J C, Gjerset G, Anasetti C
机构信息
Fred Hutchinson Cancer Research Center, Seattle, Washington.
出版信息
Immunology. 1993 Jul;79(3):509-11.
In order to investigate the function of CD2 and CD18 receptors in antibody-dependent cellular cytotoxicity (ADCC), Fab' fragments of the monoclonal antibodies 9.6 (anti-CD2) and 60.3 (anti-CD18) were preincubated with the human natural killer (NK) clone EB4.19 and tested for conjugate formation and cytotoxic function against the human B-cell line KMS and the mouse thymoma line SL-2. We concluded that: (1) the FcR CD16 does not participate in conjugate formation; (2) adhesion between target and effector cells mediated by CD2 and CD18 is a prerequisite for subsequent activation of the lytic programme through the CD16 receptor.
为了研究CD2和CD18受体在抗体依赖性细胞毒性（ADCC）中的作用，将单克隆抗体9.6（抗CD2）和60.3（抗CD18）的Fab'片段与人自然杀伤（NK）克隆EB4.19预孵育，并检测其与人类B细胞系KMS和小鼠胸腺瘤系SL-2的结合形成及细胞毒性功能。我们得出以下结论：（1）FcR CD16不参与结合形成；（2）由CD2和CD18介导的靶细胞与效应细胞之间的黏附是随后通过CD16受体激活裂解程序的前提条件。
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