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一种与多种细胞介导免疫功能相关的常见白细胞细胞表面抗原(Lp95 - 150)的定义。

Definition of a common leukocyte cell-surface antigen (Lp95-150) associated with diverse cell-mediated immune functions.

作者信息

Beatty P G, Ledbetter J A, Martin P J, Price T H, Hansen J A

出版信息

J Immunol. 1983 Dec;131(6):2913-8.

PMID:6644024
Abstract

We have described a monoclonal antibody, designated 60.3, which reacts with a cell surface antigen expressed by most peripheral blood and bone marrow leukocytes. Immunoprecipitation showed at least three major components with relative m.w. of 95,000, 130,000, and 150,000 under reducing conditions. Antibody 60.3 inhibited several cell-mediated immune functions. The lytic activity of both cytotoxic T cells and natural killer cells was blocked in the presence of the antibody. The proliferative responses of T cells stimulated by soluble antigens, mitogens, or allogeneic cells were inhibited when antibody 60.3 was added at the initiation of culture, but not when added after 48 hr. Antibody 60.3 also blocked the migration of neutrophilic granulocytes. The antigen identified by antibody 60.3 thus appears to be involved in a membrane-dependent cell activation pathway that is common to diverse functional systems and is shared by both lymphoid and myeloid cells.

摘要

我们已经描述了一种单克隆抗体,命名为60.3,它可与大多数外周血和骨髓白细胞表达的一种细胞表面抗原发生反应。免疫沉淀显示,在还原条件下至少有三个主要成分,相对分子量分别为95,000、130,000和150,000。抗体60.3抑制了几种细胞介导的免疫功能。在抗体存在的情况下,细胞毒性T细胞和自然杀伤细胞的裂解活性均被阻断。当在培养开始时加入抗体60.3时,可溶性抗原、有丝分裂原或同种异体细胞刺激的T细胞增殖反应受到抑制,但在48小时后加入则不受影响。抗体60.3还阻断了嗜中性粒细胞的迁移。因此,抗体60.3识别的抗原似乎参与了一种膜依赖性细胞激活途径,该途径在不同的功能系统中是常见的,并且淋巴细胞和髓细胞都有。

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