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含P1抗原的禽蛋清作为泌尿道脓毒症患者野生型大肠杆菌菌株中P黏附素的抑制剂。

P1-antigen-containing avian egg whites as inhibitors of P adhesins among wild-type Escherichia coli strains from patients with urosepsis.

作者信息

Johnson J R, Ross A E

机构信息

Department of Medicine, University of Minnesota, Minneapolis 55455.

出版信息

Infect Immun. 1993 Nov;61(11):4902-5. doi: 10.1128/iai.61.11.4902-4905.1993.

Abstract

Among 58 Escherichia coli urosepsis isolates, P1-antigen-containing dove and pigeon egg whites were significantly more effective inhibitors of P-adhesin-specific agglutination than were chicken egg whites or globoside. Globoside's inefficacy may have resulted from a proadherence effect of globoside's lipid tail. Adhesin phenotypes determined with dove and pigeon egg whites as as agglutination inhibitors corresponded closely with phenotypes defined by comparative hemagglutination of human P1 and p erythrocytes. These data suggest that avian P1-antigen-containing substances may provide a useful alternative method for P adhesin inhibition among uropathogenic E. coli strains.

摘要

在58株大肠杆菌泌尿道感染分离株中,含P1抗原的鸽蛋和鸽蛋清对P-黏附素特异性凝集的抑制作用明显强于鸡蛋白或红细胞糖苷脂。红细胞糖苷脂无效可能是由于其脂尾的促黏附作用。以鸽蛋和鸽蛋清作为凝集抑制剂所确定的黏附素表型与通过人P1和p红细胞比较血凝所定义的表型密切相关。这些数据表明,含禽类P1抗原的物质可能为抑制尿路致病性大肠杆菌菌株中的P黏附素提供一种有用的替代方法。

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