来自比利时两家综合医院的耐氨基糖苷类铜绿假单胞菌分离株的血清型及超广谱β-内酰胺耐药性：一项为期七年的研究

Serotypes and extended spectrum beta-lactam resistance in aminoglycoside resistant Pseudomonas aeruginosa isolates from two Belgian general hospitals: a seven year study.

作者信息

Vanhoof R, Godard C, Nulens E, Nyssen H J, Wildemauwe C, Hubrechts J M, Maes P, Hannecart-Pokorni E

机构信息

Unit of Antibiotic Research, Institute Pasteur of Brabant, Brussels, Belgium.

出版信息

J Hosp Infect. 1993 Jun;24(2):129-38. doi: 10.1016/0195-6701(93)90075-b.

DOI:10.1016/0195-6701(93)90075-b

PMID:8104976

Abstract

A total of 1896 isolates of Pseudomonas aeruginosa resistant to aminoglycosides and isolated during the period 1983-1989 in two Belgian general hospitals were included in this study. The most frequently encountered O serotypes were O4, O11, O12 and non-typable isolates. The majority of the isolates showed resistance to extended spectrum beta-lactam antibiotics (cefotaxime, ceftriaxone and cefepime). However, a low degree of resistance was found for ceftazidime. By contrast, amikacin and isepamicin, remained active on a significant number of aminoglycoside resistant isolates. In both hospitals, impermeability and AAC(3)II enzyme production were the most prevalent aminoglycoside resistance mechanisms. There were marked differences between the two hospitals with regard to the distribution of the O-serotypes and resistance profiles.

摘要

本研究纳入了1983年至1989年期间在比利时两家综合医院分离出的1896株对氨基糖苷类耐药的铜绿假单胞菌。最常遇到的O血清型是O4、O11、O12以及不可分型菌株。大多数分离株对超广谱β-内酰胺抗生素（头孢噻肟、头孢曲松和头孢吡肟）耐药。然而，发现对头孢他啶的耐药程度较低。相比之下，阿米卡星和异帕米星对大量耐氨基糖苷类的分离株仍有活性。在两家医院中，通透性降低和AAC(3)II酶产生是最常见的氨基糖苷类耐药机制。两家医院在O血清型分布和耐药谱方面存在显著差异。