Hisano S, Chikamori-Aoyama M, Aizawa T, Fukui Y
Department of Anatomy, School of Medicine, University of Tokushima, Japan.
Neurosci Lett. 1993 Jun 25;156(1-2):21-3. doi: 10.1016/0304-3940(93)90429-o.
By double label immunohistochemistry, we studied the synaptic relation between somatostatin (SS) and oxytocin (OT) or vasopressin (VP) neurons in the paraventricular nucleus (PVN) of the rat hypothalamus. In the light microscopic observation, SS-immunoreactive (ir) fibers were seen very frequently in contact with OT-ir neurons, but not with VP-ir neurons. Immunoelectron microscopic analysis revealed that somata and their dendrites of OT-ir magnocellular neurons were in synaptic contacts with SS-ir axon terminals. No SS-ir synaptic terminals were found on VP-ir magnocellular neurons. The results suggest that OT-containing magnocellular neurons in the PVN are under regulatory influences of SS-containing neurons.
通过双重免疫组织化学方法，我们研究了大鼠下丘脑室旁核（PVN）中生长抑素（SS）与催产素（OT）或加压素（VP）神经元之间的突触关系。在光学显微镜观察中，可见SS免疫反应性（ir）纤维经常与OT-ir神经元接触，但不与VP-ir神经元接触。免疫电子显微镜分析显示，OT-ir大细胞神经元的胞体及其树突与SS-ir轴突终末形成突触联系。在VP-ir大细胞神经元上未发现SS-ir突触终末。结果表明，PVN中含OT的大细胞神经元受到含SS神经元的调节影响。
