Fogolari F, Esposito G, Viglino P, Damante G, Pastore A
Dipartimento di Scienze e Tecnologie Biomediche, Facoltà di Medicina, Università di Udine, Italy.
Protein Eng. 1993 Jul;6(5):513-9. doi: 10.1093/protein/6.5.513.
A possible structure for the homeodomain of rat thyroid transcription factor 1 is proposed on the basis of the homology with other homeodomains whose structures have been solved by X-ray crystallography. A structure very similar to the reference ones is feasible and may account for the observed DNA-binding specificity. Structural features of the model, which are likely to be shared by other homeodomains, are discussed and may help researchers in the field to analyse their own experimental data.
基于与其他已通过X射线晶体学解析结构的同源异型结构域的同源性，提出了大鼠甲状腺转录因子1同源异型结构域的一种可能结构。一种与参考结构非常相似的结构是可行的，并且可以解释所观察到的DNA结合特异性。讨论了该模型的结构特征，这些特征可能为其他同源异型结构域所共有，可能有助于该领域的研究人员分析他们自己的实验数据。
