Koga Y, Swanson V L, Hays D M
J Pediatr Surg. 1975 Oct;10(5):641-8. doi: 10.1016/0022-3468(75)90367-x.
In 23 patients who received fat emulsion (Intralipid) intravenously and had subsequent necropsy, the deposition of pigment in the liver was evaluated quantitatively. Pigment was found in hepatic cells (HC) in 14 of 23 patients as well as reticuloendothelial cells (REC) in 22 of 23 patients. There was more pitment deposition in HC in younger children. HC pigment deposition occurred most frequently in patients with acute inflammatory processes within the abdomen. Patients infused with emulsion at rates less than 0.5 g/kg body wt/hr had less pigment deposition than patients infused at faster rates. Neonates infused at rates less than 0.2 g/kg body wt/hr for 24 hr had less HC pigment than neonates infused at higher rates. The quantity of REC pigment bore no apparent relationship to age, clinical diagnosis, rate or total dose of fat emulsion, but was increased in groups infused more than 14 days.
对23例接受静脉注射脂肪乳剂（英脱利匹特）并随后进行尸检的患者，对肝脏中的色素沉积进行了定量评估。在23例患者中，14例在肝细胞（HC）中发现色素，23例中的22例在网状内皮细胞（REC）中发现色素。年幼儿童的肝细胞中色素沉积更多。肝细胞色素沉积最常见于腹部有急性炎症过程的患者。以低于0.5 g/kg体重/小时的速率输注乳剂的患者比以更快速率输注的患者色素沉积更少。以低于0.2 g/kg体重/小时的速率输注24小时的新生儿比以更高速率输注的新生儿肝细胞色素更少。网状内皮细胞色素的量与年龄、临床诊断、脂肪乳剂的输注速率或总剂量无明显关系，但在输注超过14天的组中有所增加。
