Spohn H E, Coyne L
Menninger Clinic, Topeka, Kansas 66601-0829.
Brain Cogn. 1993 Sep;23(1):28-39. doi: 10.1006/brcg.1993.1042.
In this article we report the results of a test of the hypothesis that a form of attention/information processing dysfunction, attentional set impairment, is exacerbated by facial-oral tardive dyskinesia in schizophrenics. This hypothesis was tested in the context of a study that was aimed at determining whether the Reaction Time Crossover Effect, a well-established form of attentional set impairment in schizophrenia, was "affected" by neuroleptic treatment. Our results indicate that the crossover effect is resistant to modification by neuroleptics, but that it is exacerbated by facial-oral tardive dyskinesia. We speculate that neurophysiological mechanisms underlying tardive dyskinesia interact with or are similar to those underlying attentional set impairment.
在本文中，我们报告了一项假设检验的结果，该假设认为注意力/信息处理功能障碍的一种形式，即注意力定势受损，在精神分裂症患者中会因面部-口腔迟发性运动障碍而加剧。这一假设是在一项旨在确定反应时间交叉效应（精神分裂症中一种公认的注意力定势受损形式）是否受抗精神病药物治疗“影响”的研究背景下进行检验的。我们的结果表明，交叉效应对抗精神病药物的改变具有抗性，但会因面部-口腔迟发性运动障碍而加剧。我们推测，迟发性运动障碍背后的神经生理机制与注意力定势受损背后的机制相互作用或相似。
