Ngah W Z, Shamaan N A, Said M H, Azhar M T
Department of Biochemistry, Faculty of Medicine, University Kebangsaan Malaysia, Kuala Lumpur.
Eur Arch Otorhinolaryngol. 1993;250(5):304-7. doi: 10.1007/BF00186232.
Plasma gamma-glutamyltranspeptidase (gamma-GT), glutathione peroxidase (GPx) and glutathione reductase (GR) activities were determined in normal and nasopharyngeal carcinoma (NPC) patients. No difference in enzyme activities was observed in the three major races of the Malaysian population, i.e. Malay, Chinese and Indian patients. However, plasma gamma-GT, erythrocyte glutathione S-transferase (GST) and GPx activities were significantly increased in all NPC patients, while GR activity remained unchanged. Patients with elevated plasma gamma-GT activities also had increased GST and GPx activities. Plasma gamma-GT and GPx activities were then found to be affected by treatment. Patients with plasma gamma-GT activity greater than 70 IU/l had very poor prognoses but patients with decreased gamma-GT activities were found to be in remission.
测定了正常人和鼻咽癌（NPC）患者血浆γ-谷氨酰转肽酶（γ-GT）、谷胱甘肽过氧化物酶（GPx）和谷胱甘肽还原酶（GR）的活性。在马来西亚人口的三个主要种族，即马来族、华裔和印度裔患者中，未观察到酶活性存在差异。然而，所有NPC患者的血浆γ-GT、红细胞谷胱甘肽S-转移酶（GST）和GPx活性均显著升高，而GR活性保持不变。血浆γ-GT活性升高的患者其GST和GPx活性也增加。随后发现血浆γ-GT和GPx活性受治疗影响。血浆γ-GT活性大于70 IU/l的患者预后很差，但γ-GT活性降低的患者处于缓解期。
