Munshi A, Mehrotra R, Ramesh R, Panda S K
Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
J Med Virol. 1993 Dec;41(4):275-81. doi: 10.1002/jmv.1890410404.
Extracts of the two traditional Indian herbs, Phyllanthus amarus (P. amarus) and Phyllanthus maderaspatensis (P. maderaspatensis), described by others as useful in the treatment of chronic hepatitis B virus infection were studied for antiviral properties on duck hepatitis B virus infection. One hundred and fourteen ducks infected posthatch with the duck hepatitis B virus (DHBV) were divided into groups at three months of age and treated intraperitoneally with the aqueous, butanol, and alcoholic extracts of these two plants at doses of 25, 50, or 200 mg/kg body weight. Saline-treated animals served as controls. In the ducks negative for DHBV in serum after treatment, we observed replicative intermediates in the liver. There was no definite antiviral property observed in the treated ducks.
两种传统印度草药——苦味叶下珠和麻德拉斯叶下珠，其他人曾描述它们对治疗慢性乙型肝炎病毒感染有用，我们研究了它们对鸭乙型肝炎病毒感染的抗病毒特性。114只孵化后感染鸭乙型肝炎病毒（DHBV）的鸭子在3月龄时被分组，并以25、50或200毫克/千克体重的剂量经腹腔注射这两种植物的水提取物、丁醇提取物和乙醇提取物。用盐水处理的动物作为对照。在治疗后血清中DHBV呈阴性的鸭子中，我们在肝脏中观察到了复制中间体。在接受治疗的鸭子中未观察到明确的抗病毒特性。
