Dennin D E
MMW Munch Med Wochenschr. 1975 Oct 10;117(41):1667-70.
The experiences of English teams with continuous intravenous infusion of small doses of insulin (6-10 IU/h) for the treatment of diabetic ketoacidosis are reported. This form of therapy is based on recent knowledge of the physiological degree of the serum insulin level (20-200 muU/ml) and the quantity required to saturate the insulin receptors. The advantages of this treatment are in the low therapeutic risk: hypopotassemia, hypoglycemia and cerebral edema, which are disadvantages of conventional therapy of diabetic coma, are avoided.
据报道,英国团队采用持续静脉输注小剂量胰岛素(6 - 10国际单位/小时)治疗糖尿病酮症酸中毒的经验。这种治疗方式基于近期对血清胰岛素水平生理程度(20 - 200微单位/毫升)以及使胰岛素受体饱和所需剂量的认识。这种治疗方法的优点是治疗风险低:避免了低钾血症、低血糖和脑水肿,而这些是糖尿病昏迷传统治疗方法的缺点。