Shaw P J, Eden T, Cohen B J
Department of Haematology, Royal Hospital for Sick Children, Edinburgh.
Cancer. 1993 Aug 1;72(3):945-9. doi: 10.1002/1097-0142(19930801)72:3<945::aid-cncr2820720346>3.0.co;2-h.
Several reports have been published of anemia due to infection by parvovirus in patients receiving chemotherapy for leukemia. However, parvovirus B19 has not been previously identified as a cause of chronic anemia in children with solid tumors.
A child with rhabdomyosarcoma developed chronic anemia, with need for regular blood transfusions during chemotherapy. An infectious etiology was sought.
B19 viremia and an absent antibody response was present during the period of chronic anemia during chemotherapy. After completion of chemotherapy, the viremia cleared, IgM and IgG antibody to B19 virus were detected, and the anemia resolved.
Parvovirus must be considered as a cause of anemia in patients undergoing chemotherapy for solid tumors as well as leukemia.
已有多篇关于接受白血病化疗的患者感染细小病毒导致贫血的报道。然而，此前细小病毒B19尚未被确认为实体瘤患儿慢性贫血的病因。
一名横纹肌肉瘤患儿出现慢性贫血，化疗期间需要定期输血。对其进行了感染病因的排查。
化疗期间慢性贫血阶段存在B19病毒血症且抗体反应缺失。化疗结束后，病毒血症清除，检测到针对B19病毒的IgM和IgG抗体，贫血得到缓解。
对于接受实体瘤及白血病化疗的患者，必须考虑细小病毒为贫血的病因。
