Mravcová A, Jírová D, Jancí H, Lener J
National Institute of Public Health, Prague, Czechoslovakia.
Sci Total Environ. 1993;Suppl Pt 1:663-9. doi: 10.1016/s0048-9697(05)80069-5.
Experiments were carried out to gain more information on the effects of long term exposure to low doses of vanadium administered to mice and rats in drinking water. The selective immunotoxic effects of vanadium were depression of phagocytosis, splenotoxicity, enlargement of spleen, elevation of peripheral blood leucocytes and T and B cell activation. Vanadium accumulates in hard tissues and influences the mineralisation of epiphyseal cartilage. This effect is obviously evident in young animals. Significant differences in vanadium concentration were found between young and adult animals.
进行了实验，以获取更多关于长期给小鼠和大鼠饮用低剂量钒水的影响的信息。钒的选择性免疫毒性作用包括吞噬作用抑制、脾毒性、脾脏肿大、外周血白细胞升高以及T细胞和B细胞活化。钒在硬组织中蓄积，并影响骺软骨的矿化。这种作用在幼龄动物中明显可见。在幼龄动物和成年动物之间发现了钒浓度的显著差异。
