Lukina E A, Kuznetsov V P, Beliaev D L, Kaplanskaia I B, Mokeeva R A
Ter Arkh. 1993;65(11):67-70.
Langerhans cell histiocytosis (LCH) and histiocytosis class II (without Langerhans cells) were treated in 10 and 2 patients, respectively, with alpha-interferon preparations: recombinant alpha 2-interferon and two combined preparations containing natural alpha-interferon and immune response phase 1 cytokines. The patients' age ranged from 18 to 61 years, all of them had multiple lesions. Six of them exhibited dysfunctions of the affected organs. As shown by the results of 16-52-month follow-up, LCH patients' disease persisted in chronic active stage without progression (8 cases) or reached a complete remission (1 case), one patient died. In histiocytosis class II alpha-interferon administration was uneffective.
朗格汉斯细胞组织细胞增多症（LCH）和II类组织细胞增多症（无朗格汉斯细胞）分别有10例和2例患者接受了α-干扰素制剂治疗：重组α2-干扰素以及两种含有天然α-干扰素和免疫反应1期细胞因子的联合制剂。患者年龄在18至61岁之间，均有多处病变。其中6例出现受累器官功能障碍。16至52个月的随访结果显示，LCH患者的疾病处于慢性活动期且无进展（8例）或达到完全缓解（1例），1例患者死亡。在II类组织细胞增多症中，使用α-干扰素无效。
