Kushlinskiĭ N E, Nagibin A A, Laptev P I, Parshikova S M, Bassalyk L S, Matiakin E G, Mikhaĭlovskiĭ A V
Stomatologiia (Mosk). 1993 Oct-Dec;72(4):18-22.
The paper deals with the studies of sexual steroidal hormone receptors in the tumor cytosolic fraction in 37 patients with squamous cell carcinoma and in 18 patients from leukoplakia foci in the oral mucosa. One or two types of androgen and estrogen receptors were detected in the tumor cytosolic fraction in most female (75%) and male (62%) patients with squamous cell carcinoma. The detection rate and the mean values of androgen and estrogen receptors in squamous cell carcinoma of the oral mucosa were associated with sex, age, disease stage, type of growth and site of a tumor. Detection and levels of androgen and estrogen receptors in the leukoplakia foci of the oral mucosa depended on the age of patients. Cytoplasmic estrogen receptors (50%) and oral mucosal squamous cell cancer (34.4%) were much more encountered in the foci of leukoplakia and their mean levels tended to increase. The mechanism of action of sexual steroids on normal and tumor target cells, the role of androgens and estrogens in the pathogenesis of oral mucosal carcinoma and leukoplakia, and possible methods of endocrine therapy for these diseases are discussed.
本文研究了37例鳞状细胞癌患者及18例口腔黏膜白斑病灶患者肿瘤胞质部分中的性甾体激素受体。在大多数女性（75%）和男性（62%）鳞状细胞癌患者的肿瘤胞质部分中检测到一种或两种雄激素和雌激素受体。口腔黏膜鳞状细胞癌中雄激素和雌激素受体的检出率及平均值与性别、年龄、疾病分期、生长类型及肿瘤部位有关。口腔黏膜白斑病灶中雄激素和雌激素受体的检测及水平取决于患者年龄。在白斑病灶中更常遇到细胞质雌激素受体（50%）和口腔黏膜鳞状细胞癌（34.4%），且其平均水平有升高趋势。文中讨论了性甾体对正常及肿瘤靶细胞的作用机制、雄激素和雌激素在口腔黏膜癌及白斑发病机制中的作用，以及这些疾病可能的内分泌治疗方法。
