van der Westhuysen J M, Jones J J, van Niekerk C H
S Afr Med J. 1975 Oct 11;49(43):1799-803.
Plasma renin activity was found to be correlated positively with muscle water content and the presence of oedema in rats with protein energy malnutrition, whereas the muscle potassium content showed a negative correlation with muscle water content. Malnourished rats also showed an inability to dispose of a water load. Nevertheless, the ability of malnourished rats to excrete injected hormones and to clear the plasma of bromosulphthalein proved to be normal. It is therefore concluded that, although the inability to balance consumption and excretion of water may in part be the result of increased effective plasma renin activity, the increased plasma concentration results from increased secretion rather than from decreased inactivation.
在蛋白质能量营养不良的大鼠中，发现血浆肾素活性与肌肉含水量及水肿的存在呈正相关，而肌肉钾含量与肌肉含水量呈负相关。营养不良的大鼠还表现出无法处理水负荷。然而，营养不良的大鼠排泄注射激素和清除血浆中溴磺酞的能力被证明是正常的。因此得出结论，尽管无法平衡水的摄入和排泄可能部分是有效血浆肾素活性增加的结果，但血浆浓度升高是由于分泌增加而非灭活减少所致。
