Van der Westhuysen J M, Kanengoni E, Mbizvo M, Jones J J
S Afr Med J. 1977 Jan 1;51(1):18-20.
Five litter-mate male pigs, aged 7 days and fed a standard Pig Industry Board diet containing 190 g/kg dry mass of digestible protein, were compared with 10 male pigs from two litters fed a protein-deficient diet (50 g/kg) for a period of 70 days. The 10 experimental animals developed oedema between the 42nd and 70th days of the study and 4 of them became lethargic. Although the 10 experimental animals showed the typical biochemical changes characteristic of protein energy malnutrition (PEM), including changes in muscle electrolytes, liver fat and plasma albumin, the 4 lethargic animals showed a significant increase in effective plasma renin activity (EPRA) only by the 70th day of the study. Since oedema preceded any increase in EPRA in some pigs and developed in others without any change in EPRA, it is suggested that the increased renin activity is not responsible for the initial fluid retention and oedema.
将5只7日龄、喂食含有190克/千克干物质可消化蛋白质的标准养猪业委员会日粮的同窝雄性仔猪，与来自两窝喂食蛋白质缺乏日粮（50克/千克）70天的10只雄性仔猪进行比较。10只实验动物在研究的第42天至第70天之间出现水肿，其中4只变得嗜睡。尽管10只实验动物表现出蛋白质能量营养不良（PEM）的典型生化变化，包括肌肉电解质、肝脏脂肪和血浆白蛋白的变化，但4只嗜睡动物仅在研究的第70天显示有效血浆肾素活性（EPRA）显著增加。由于在一些猪中水肿先于EPRA的任何增加，而在另一些猪中水肿发生时EPRA没有任何变化，因此提示肾素活性增加不是最初液体潴留和水肿的原因。
