Benitez del Castillo J M, Castillo A, Garcia Sanchez J, Ruibal J L, Reverte F, Ibarra J M
Department of Ophthalmology, Hospital Universitario San Carlos, Universidad Complutense de Madrid, Spain.
Acta Ophthalmol (Copenh). 1993 Oct;71(5):651-6. doi: 10.1111/j.1755-3768.1993.tb04655.x.
The authors assessed a fluorophotometry follow-up study of 18 months in 24 juvenile insulin-dependent diabetic patients with no retinopathy. The initial duration of diabetes was 5.96 +/- 3.44 years and the glycosylated hemoglobin (HbA1c) was 10.12 +/- 2.27%. The baseline Vitreous Penetration Ratio transmittance value (VPRt) was 4.13 +/- 1.31 x 10-6 min-1 and after 18 months was 5.36 +/- 1.85 x 10-6 min-1, yielding a statistically significant difference (p < 0.01). The average HbA1c during the follow-up term was 9.80 +/- 1.72%. VPRt values were significantly correlated with the duration of diabetes and HbA1c. During the follow-up 3 patients developed foveal background diabetic retinopathy with respect to a high initial VPRt value (6.22 +/- 0.27 x 10-6 min-1), nevertheless, the other 7 patients with high baseline VPRt did not do so. We suggest that vitreous fluorophotometry could be a beneficial procedure in the management of insulin-dependent diabetic patients; however, there is not a cut-off value for VPRt values to help distinguish patients prone to develop retinopathy.
作者评估了24例无视网膜病变的青少年胰岛素依赖型糖尿病患者的18个月荧光光度随访研究。糖尿病的初始病程为5.96±3.44年，糖化血红蛋白（HbA1c）为10.12±2.27%。基线玻璃体透过率（VPRt）值为4.13±1.31×10⁻⁶ min⁻¹，18个月后为5.36±1.85×10⁻⁶ min⁻¹，差异有统计学意义（p<0.01）。随访期间平均HbA1c为9.80±1.72%。VPRt值与糖尿病病程和HbA1c显著相关。随访期间，3例患者因初始VPRt值较高（6.22±0.27×10⁻⁶ min⁻¹）出现了黄斑背景性糖尿病视网膜病变，然而，其他7例基线VPRt值较高的患者并未出现这种情况。我们认为玻璃体荧光光度法可能是管理胰岛素依赖型糖尿病患者的一种有益方法；然而，VPRt值没有一个临界值来帮助区分易患视网膜病变的患者。
