Gwynn D R, Stewart W C, Hennis H L, McMillan T A, Pitts R A
Department of Ophthalmology, Medical University of South Carolina, Charleston.
Acta Ophthalmol (Copenh). 1993 Oct;71(5):691-5. doi: 10.1111/j.1755-3768.1993.tb04663.x.
We evaluated the influence of age upon conjunctival structure and number of inflammatory cells by studying perioperative conjunctival biopsies from 54 consecutive primary open-angle glaucoma patients undergoing initial filtering surgery (trabeculectomy alone or combined cataract extraction and trabeculectomy). All patients had received chronic topical glaucoma therapy for > 1 year. We divided the patients into three age groups for analysis: 40-60 (n = 10), 61-74 (n = 28), and > 75 (n = 16) years. We found no statistical difference (p > 0.05, chi-square) in cell counts of neutrophils, eosinophils, mast cells, macrophages, fibroblasts, lymphocytes, plasma cells and goblet cells across the three age groups. In addition, no statistical differences were observed between age groups in vascular density, epithelial thickness as well as mucopolysaccharide and collagen composition (p > 0.05, chi square). This study suggests that conjunctival structure and inflammatory cell counts change little with advancing age in primary open-angle glaucoma patients.
我们通过研究54例连续接受初次滤过手术（单纯小梁切除术或联合白内障摘除及小梁切除术）的原发性开角型青光眼患者的围手术期结膜活检样本，评估了年龄对结膜结构和炎性细胞数量的影响。所有患者均接受了超过1年的慢性青光眼局部治疗。我们将患者分为三个年龄组进行分析：40 - 60岁（n = 10）、61 - 74岁（n = 28）和75岁以上（n = 16）。我们发现，在这三个年龄组中，中性粒细胞、嗜酸性粒细胞、肥大细胞、巨噬细胞、成纤维细胞、淋巴细胞、浆细胞和杯状细胞的细胞计数无统计学差异（p > 0.05，卡方检验）。此外，各年龄组在血管密度、上皮厚度以及粘多糖和胶原蛋白组成方面也未观察到统计学差异（p > 0.05，卡方检验）。这项研究表明，在原发性开角型青光眼患者中，结膜结构和炎性细胞计数随年龄增长变化不大。
