Gwynn D R, Stewart W C, Pitts R A, McMillan T A, Hennis H L
Department of Ophthalmology, Medical University of South Carolina, Charleston 29425-2236.
Am J Ophthalmol. 1993 Oct 15;116(4):464-8. doi: 10.1016/s0002-9394(14)71405-9.
We evaluated perioperative conjunctival biopsy specimens in 28 consecutive patients with primary open-angle glaucoma undergoing trabeculectomy who had not undergone previous intraocular surgery. We found six months postoperatively that the number of goblet cells was significantly greater (6.40 +/- 5.40 vs 1.68 +/- 1.60 per field of view; P = .004, Student's t-test) in patients with easier postoperative intraocular pressure control (intraocular pressure < or = 15 mm Hg with zero to two glaucoma medications) than in patients with more difficult intraocular pressure control (> 15 mm Hg with three or more glaucoma medications). No statistical differences between groups were observed in mast cells, neutrophils, eosinophils, macrophages, plasma cells, lymphocytes, or fibroblasts (P > .05). Also, no statistical difference between groups existed in conjunctival structure, including mucopolysaccharide and collagen composition, vascular density, or epithelial thickness (P > .05). This study suggests that the number of conjunctival goblet cells may be related to intraocular pressure control after trabeculectomy.
我们评估了28例连续接受小梁切除术的原发性开角型青光眼患者的围手术期结膜活检标本，这些患者此前未接受过眼内手术。我们在术后六个月发现，术后眼压控制较容易的患者（眼压≤15 mmHg，使用零至两种青光眼药物）结膜杯状细胞数量显著多于眼压控制较困难的患者（眼压>15 mmHg，使用三种或更多种青光眼药物）（每个视野6.40±5.40 vs 1.68±1.60；P = 0.004，Student t检验）。两组在肥大细胞、中性粒细胞、嗜酸性粒细胞、巨噬细胞、浆细胞、淋巴细胞或成纤维细胞方面未观察到统计学差异（P>0.05）。此外，两组在结膜结构方面也无统计学差异，包括粘多糖和胶原蛋白组成、血管密度或上皮厚度（P>0.05）。这项研究表明，结膜杯状细胞数量可能与小梁切除术后的眼压控制有关。
