Waldherr R, Mall G, Rossner J A, Schärer K
Virchows Arch A Pathol Anat Histol. 1975 Oct 7;368(1):73-86. doi: 10.1007/BF00432168.
Kidney biopsy specimens of three patients with a special form of hypoplasia, the oligomeganephronic hypoplasia (Oligomeganephronie) were studied with light- and electron-microscopy as well as morphometric methods. The morphometric measurements demonstrated that there were no quantitative differences of the glomerular components between normal and oligomeganephronic glomeruli of patients of the same age. All of the structures measured--glomerular capillary surface, glomerular volume, volume of the glomerular capillary lumina and volume of Bowman's capsular space--were increased about 5.4 times. The volume of the proximal and distal tubules per mum tubular length in oligomeganephronic patients was disproportionally increased. The total number of glomeruli was more diminuished than mentionned in the literature until this time. The secondary glomerular sclerosis, initially focal, was progressive and supposed to be caused by "chronic overwork".
对三名患有特殊形式肾发育不全即少肾小球肾发育不全（Oligomeganephronie）患者的肾活检标本进行了光镜、电镜及形态计量学研究。形态计量学测量表明，同一年龄患者的正常肾小球和少肾小球肾发育不全的肾小球之间，肾小球成分无数量差异。所有测量结构——肾小球毛细血管表面积、肾小球体积、肾小球毛细血管腔体积和鲍曼囊腔体积——均增加了约5.4倍。少肾小球肾发育不全患者每毫米肾小管长度的近端和远端小管体积不成比例地增加。肾小球总数比此前文献中提到的减少得更多。继发性肾小球硬化最初为局灶性，呈进行性，推测是由“慢性负荷过重”所致。
