Blum S, Singh T P, Gibbons J, Fordyce E J, Lessner L, Chiasson M A, Weisfuse I B, Thomas P A
New York City Department of Health, New York.
Am J Epidemiol. 1994 Feb 15;139(4):351-61. doi: 10.1093/oxfordjournals.aje.a117007.
This study examined survival trends among the 23,324 cases of acquired immunodeficiency syndrome (AIDS) meeting the Centers for Disease Control (CDC) definition that were diagnosed and reported to the New York City Department of Health from the beginning of the epidemic in 1980 through June 1989. The survival patterns of 20,760 individuals who survived for at least 1 calendar month beyond diagnosis were analyzed; all survival analyses were truncated at December 1, 1990, 17 months after the last diagnosis. Persons who died during the same month in which they were diagnosed ("zero" survivors) were excluded. Cases were examined by race/ethnicity, sex, age at diagnosis, calendar period of diagnosis, transmission category, CDC AIDS case definition (prior to and after the 1987 change in the AIDS case definition), and nature of diagnosis. Results of two- and three-way categorical analysis and logistic regression analysis are reported. Overall median survival time was 13.7 months (14.0 for males and 12.0 for females). Survival was better for whites than for blacks and Hispanics and was better for men who had sex with men than for injecting drug users. Each of the seven demographic and risk behavior factors was independently associated with survival. Trends in survival during three time periods indicated that survival is improving among all groups examined.
本研究调查了1980年疫情开始至1989年6月期间,纽约市卫生部门诊断并报告的23324例符合美国疾病控制中心(CDC)定义的获得性免疫缺陷综合征(AIDS)病例的生存趋势。分析了20760例诊断后存活至少1个日历月的个体的生存模式;所有生存分析均在1990年12月1日截止,即最后一次诊断后的17个月。排除在诊断当月死亡的患者(“零”存活者)。按种族/族裔、性别、诊断时年龄、诊断日历期、传播类别、CDC艾滋病病例定义(1987年艾滋病病例定义变更前后)以及诊断性质对病例进行了检查。报告了双向和三向分类分析以及逻辑回归分析的结果。总体中位生存时间为13.7个月(男性为14.0个月,女性为12.0个月)。白人的生存率高于黑人和西班牙裔,男男性行为者的生存率高于注射吸毒者。七个人口统计学和风险行为因素中的每一个都与生存独立相关。三个时间段的生存趋势表明,所有受检群体的生存率都在提高。