Lopp L Kh, Belitskiĭ G A
Vopr Onkol. 1975;21(10):50-5.
Induction of skin tumors by 7,12-dimethylbenz(a)anthracene (DMBA) in the presence of its metabolites-7-hydroxymethyl-12-methylbenz(a)anthracene (7-OHM-12-MBA) and 7,12-dihydroxymethylbenz(a)anthracene (7,12-diOHMBA) has been studied in mice. The skin of mice was treated repeatedly with benzene or acetone solutions of DMBA (22 mug in two droplets) or with the same amount of DMBA solution together with one of the above mentioned metabolites (the molecular ratio 1 : 1 or 1 : 0.5). Neither of the metabolites affected the carcinogenic activity of DMBA under the given conditions. 7,8-benzoflavone, an inhibitior of the DMBA metabolism, strongly suppressed DMBA tumorigenesis under the same experimental conditions. Whereas the effect of benz(a)-anthracene, an inducer of aryl hydrocarbon hydroxylase activity, was less pronounced.
在小鼠中研究了7,12-二甲基苯并(a)蒽（DMBA）及其代谢产物7-羟甲基-12-甲基苯并(a)蒽（7-OHM-12-MBA）和7,12-二羟甲基苯并(a)蒽（7,12-diOHMBA）诱发皮肤肿瘤的情况。用DMBA的苯溶液或丙酮溶液（两滴含22微克）反复处理小鼠皮肤，或用等量的DMBA溶液与上述一种代谢产物（分子比为1:1或1:0.5）一起处理。在给定条件下，两种代谢产物均未影响DMBA的致癌活性。DMBA代谢抑制剂7,8-苯并黄酮在相同实验条件下强烈抑制DMBA的肿瘤发生。而芳烃羟化酶活性诱导剂苯并(a)蒽的作用则不太明显。
