Belitskiĭ G A, Lopp A Kh, Khesina A Ia
Tsitologiia. 1975 Dec;17(12):1415-20.
The naturally occurring hydroxymethyl derivatives of the carcinogen 7,12-dimethylbenz(a)anthracene was found to inhibit the metabolic hydroxylation and toxic effect of this carcinogen in mouse embryo fibroblast-like cell culture. The greatest reduction of both effects was obtained when 12-hydroxymethyl-7-methylbenz(a)anthracene was added to the growth medium, less effective were, resp., 7,12-dihydroxymethylbenz(a)-anthracene and 7-hydroxymethyl-12-methylbenz(a)anthracene. The data obtained are discussed in terms of the intracellular regulation of carcinogenic hydrocarbon metabolism.
