Swain R A, Thompson R F
Neurosciences Program, University of Southern California, Los Angeles 90089.
Ann N Y Acad Sci. 1993 Nov 17;702:27-39. doi: 10.1111/j.1749-6632.1993.tb17240.x.
The body of literature presented in this paper indicate, as Marr and Albus hypothesized, that the cerebellum is involved in the regulation of classical conditioning. At present, the most parsimonious hypothesis is that the essential memory traces for classical conditioning of eyelid closure, limb flexion, and other discrete responses learned with an aversive US are formed in cerebellar cortex and interpositus nucleus. Both sites contain neuronal elements which encode both conditioned and unconditioned stimuli. Recordings from both cerebellar cortex and the deep nuclei model the topography of the conditioned response and precede the response in time. Lesions of the cortex massively impair conditioning and lesions of the interpositus nucleus completely and permanently abolish the conditioned response without affecting reflex performance.
如本文所呈现的文献表明，正如马尔和阿尔布斯所假设的那样，小脑参与经典条件反射的调节。目前，最简洁的假设是，用于眼睑闭合、肢体屈曲以及其他通过厌恶性非条件刺激习得的离散反应的经典条件反射的基本记忆痕迹，是在小脑皮层和间位核中形成的。这两个部位都包含对条件刺激和非条件刺激进行编码的神经元成分。从小脑皮层和深部核团记录的数据模拟了条件反应的地形图，并且在时间上先于反应出现。皮层损伤会严重损害条件反射，而间位核损伤会完全且永久性地消除条件反应，同时不影响反射表现。
