Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey Newark, NJ, USA ; New Jersey Medical School, Stress and Motivated Behavior Institute, University of Medicine and Dentistry of New Jersey Newark, NJ, USA.
Front Hum Neurosci. 2013 Jul 5;7:348. doi: 10.3389/fnhum.2013.00348. eCollection 2013.
Behavioral inhibition (BI) increases vulnerability to develop anxiety disorders and is typified by avoidance and withdrawal from novel objects, people, and situations. The present study considered the relationship between BI and temperamental risk factors, such as trait anxiety and acquisition rate of a classically conditioned eyeblink response. One-hundred seventy-four healthy undergraduate students (mean age 20.3 years, 71.8% female) were given the State-Trait Anxiety Inventory and a battery of self-report measures of BI consisting of the Adult and Retrospective Measures of Behavioral Inhibition (AMBI/RMBI) and the Concurrent and Retrospective Self Report of Inhibition (CSRI/RSRI). Participants then underwent standard delay classical eyeblink conditioning consisting of 45 trials with a 500-ms CS overlapping and co-terminating with a 10-ms airpuff US. Individuals with higher scores on the AMBI and Trait Anxiety Inventory, but not the other measures, showed faster acquisition of a conditioned eyeblink response than individuals with lower scores. Results support a relationship between facilitated acquisition of inter-stimulus relationships and risk for anxiety, and suggest that some measures assessing anxiety vulnerability better capture this relationship than others.
行为抑制（BI）增加了患焦虑障碍的易感性，其特征是避免和回避新奇的物体、人和情况。本研究考虑了 BI 与气质风险因素之间的关系，例如特质焦虑和经典条件反射眨眼反应的获得率。174 名健康的大学生（平均年龄 20.3 岁，71.8%为女性）接受了状态-特质焦虑量表和一系列行为抑制的自我报告测量，包括成人和回顾性行为抑制量表（AMBI/RMBI）以及同时性和回顾性自我报告的抑制（CSRI/RSRI）。然后，参与者接受了标准的延迟经典眨眼条件反射，包括 45 次试验，500ms 的 CS 与 10ms 的空气冲击 US 重叠并同时结束。AMBI 和特质焦虑量表得分较高的个体比得分较低的个体更快地获得条件反射眨眼反应。结果支持了刺激间关系的易获得性与焦虑风险之间的关系，并且表明一些评估焦虑易感性的测量方法比其他方法更好地捕捉到了这种关系。
