Akwari O E, Dozois R R, Weiland L H, Beahrs O H
Cancer. 1978 Sep;42(3):1375-84. doi: 10.1002/1097-0142(197809)42:3<1375::aid-cncr2820420348>3.0.co;2-4.
From 1950 through 1974, a total of 108 cases of primary intestinal leiomyosarcoma were seen at the Mayo Clinic. Most of these uncommon tumors occurred in the fifth and sixth decades of life, and more of them in men than in women (2.6:1). There were 73% in the small bowel, 25% in the large bowel, and 2% in the anus. Gastrointestinal bleeding and pain were the two most common signs at presentation, and they led to surgical exploration in all cases where they appeared. By the time surgery was performed, only 48% of the tumors could be resected with hope of cure. Within that group of cases, 50% of the patients survived 5 years, but only 35% survived 10 years, late recurrence being common. The histologic grade of the tumor affected survival to erroneous early optimism in prognosis.
1950年至1974年期间，梅奥诊所共收治了108例原发性肠道平滑肌肉瘤患者。这些罕见肿瘤大多发生在50至60岁之间，男性患者多于女性患者（比例为2.6:1）。其中73%位于小肠，25%位于大肠，2%位于肛门。胃肠道出血和疼痛是最常见的首发症状，所有出现这些症状的患者均接受了手术探查。在进行手术时，只有48%的肿瘤有望通过切除治愈。在这组病例中，50%的患者存活了5年，但只有35%的患者存活了10年，晚期复发很常见。肿瘤的组织学分级影响生存情况，导致预后出现错误的早期乐观判断。
