Yuksel B, Greenough A, Karani J
Department of Child Health, King's College Hospital, London, UK.
Acta Paediatr. 1993 Nov;82(11):944-7. doi: 10.1111/j.1651-2227.1993.tb12605.x.
The aim of this study was to assess if the chest radiograph appearance at seven days of age could be used to predict chronic lung disease (oxygen dependency at 28 days of age). Sixty preterm infants (median gestational age 28 weeks), who were ventilated and/or had supplementary oxygen at seven days of age and had a chest radiograph performed at that postnatal age, were prospectively recruited. These chest radiographs were scored according to lung volume, presence of opacification, haziness, interstitial changes and cystic elements (maximum score 18). Twenty-eight infants subsequently developed chronic lung disease; their median chest radiograph score was 5.5 (range 2-14) which was significantly higher than that of the non-chronic lung disease infants (median 3; range 0-6). A chest radiograph score of 4 had a 71% sensitivity and 88% specificity in predicting chronic lung disease. We conclude that chest radiograph appearance at seven days of age is a sensitive and specific predictor of chronic lung disease and thus could be used to indicate the need for preventive therapy.
本研究的目的是评估出生7天时的胸部X光片表现是否可用于预测慢性肺病（出生28天时的氧依赖情况）。前瞻性招募了60名早产婴儿（中位胎龄28周），这些婴儿在出生7天时接受了通气和/或补充氧气，并在该出生后年龄进行了胸部X光检查。根据肺容量、有无肺实变、肺模糊、间质改变和囊性成分对这些胸部X光片进行评分（最高分为18分）。随后，28名婴儿患上了慢性肺病；他们的胸部X光片评分中位数为5.5（范围2 - 14），显著高于未患慢性肺病的婴儿（中位数3；范围0 - 6）。胸部X光片评分为4时，预测慢性肺病的敏感性为71%，特异性为88%。我们得出结论，出生7天时的胸部X光片表现是慢性肺病的敏感且特异的预测指标，因此可用于表明预防性治疗的必要性。
