原发性甲状腺功能减退症中的高催乳素血症：基础和动态研究——黏液性水肿相关溢乳的意义（作者译）

[Prolactinemia in primary hypothyroïdism : basal and dynamic studies--signification of galactorrhea associated with myxedema (author's transl)].

作者信息

Fossati P, L'Hermite M, Derrien G, Golstein J, Vanhaelst L, Robyn C, Linquette M

出版信息

Ann Endocrinol (Paris). 1975 May-Jun;36(3):145-51.

Abstract

PRL and TSH were measured by radioimmuno-assay in 14 persons wth myxoedema aged 16 to 65 years. Three of them had galactorrhea. In 13 patients the circadian rhythm of PRL was studied, and in 8 patients PRL was measured after TRH administration. All these patients have a high value of serum TSH, with a mean value +/- SEM of 29,4 (24,3 - 35,6) mU/ml. Values of serum PRL were comprised in normal ranges with a mean value +/- SEM of 126(196 - 238) mU/ml. The circadian rhythm of PRL is not altered, since mean values of serum PRL are more elevated at 4 am than 8 am with highly statistical significance. After THR administration the PRL response is normal or exaggerated.

摘要

采用放射免疫分析法对14例年龄在16至65岁的黏液性水肿患者测定了催乳素（PRL）和促甲状腺激素（TSH）。其中3例有溢乳现象。对13例患者研究了PRL的昼夜节律，对8例患者在注射促甲状腺激素释放激素（TRH）后测定了PRL。所有这些患者血清TSH值均较高，平均值±标准误为29.4（24.3 - 35.6）mU/ml。血清PRL值在正常范围内，平均值±标准误为126（196 - 238）mU/ml。PRL的昼夜节律未改变，因为血清PRL平均值在凌晨4点比上午8点更高，具有高度统计学意义。注射TRH后PRL反应正常或增强。