Kapasi A A, Krishnamurthy S C, Sheth N A
Endocrinology Unit, Tata Memorial Centre, Parel, Bombay, India.
Indian J Exp Biol. 1993 Nov;31(11):863-8.
Inhibin, a 10.7 kD FSH (follicle-stimulating hormone) suppressing prostatic peptide has been shown to be synthesized and localized in stomach specimen of monkey. In vitro incorporation of labelled amino acid (3H-leucine) into inhibin followed by specific immunoprecipitation by antiserum to inhibin demonstrated an in vitro de novo biosynthesis of inhibin by monkey stomach. Moreover, the synthesis of inhibin was found to be maximum in fundic zone of gastric mucosa compared to cardiac and antral zone. This was supported by immunohistochemical study of three anatomically different regions, especially wherein fundic zone showed intense positive staining for inhibin. Furthermore, the above data was supplemented by quantitative study of tissue inhibin content by RIA which revealed that the fundic zone of gastric mucosa has a much higher concentration of inhibin than cardiac and antral region. The relationship of zonal concentration of inhibin to gastric anatomy appears to be a noteworthy observation and may serve as an useful tool in our understanding of gastric metabolism and activity.
抑制素是一种能抑制促卵泡激素（FSH）的10.7千道尔顿前列腺肽，已证实在猴的胃标本中合成并定位。通过将标记氨基酸（³H-亮氨酸）体外掺入抑制素，随后用抗抑制素抗血清进行特异性免疫沉淀，证明猴胃能在体外从头生物合成抑制素。此外，与贲门区和胃窦区相比，发现胃黏膜胃底区的抑制素合成量最大。对三个解剖结构不同区域的免疫组织化学研究支持了这一点，特别是胃底区对抑制素显示出强烈的阳性染色。此外，通过放射免疫分析对组织抑制素含量进行定量研究补充了上述数据，该研究表明胃黏膜胃底区的抑制素浓度比贲门区和胃窦区高得多。抑制素的区域浓度与胃解剖结构的关系似乎是一个值得注意的观察结果，可能成为我们理解胃代谢和活性的有用工具。
