Niederauer H H, Weindorf N, Schultz-Ehrenburg U
Abteilung Allgemeine Dermatologie mit Schwerpunkt Histopathologie und Angiologie, Ruhr-Universität Bochum im St. Josef-Hospital.
Hautarzt. 1993 Dec;44(12):795-9.
We report on a 67-year-old man with a large papillomatous tumour of the penis clinically resembling verrucous carcinoma. HPV 6 and HPV 11 DNA could be isolated by hybridization techniques. The tumour showed exclusively exophytic growth with anastomosing acanthosis and papillomatosis. Groups of vacuolated cells were present in the spinous and granular layers. Endophytic and destructive proliferations and cytologic criteria of malignancy were absent. This tumor was a giant condyloma acuminatum and not either a Buschke-Löwenstein tumour or a verrucous carcinoma. There was no recurrence 2 years after local excision. The differential diagnosis of giant condylomas and Buschke-Löwenstein tumours is discussed.
我们报告了一名67岁男性，其阴茎有一个巨大的乳头状瘤，临床上类似疣状癌。通过杂交技术可分离出HPV 6和HPV 11 DNA。肿瘤仅表现为外生性生长，伴有吻合性棘皮症和乳头瘤病。棘层和颗粒层存在成组的空泡化细胞。不存在内生性和破坏性增殖以及恶性细胞学标准。该肿瘤为巨大尖锐湿疣，而非Buschke-Löwenstein肿瘤或疣状癌。局部切除两年后未复发。讨论了巨大尖锐湿疣与Buschke-Löwenstein肿瘤的鉴别诊断。
