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老年患者中的甲状腺激素:“T4 正常甲状腺功能”

Thyroid hormones in the elderly sick: "T4 euthyroidism".

作者信息

Burrows A W, Shakespear R A, Hesch R D, Cooper E, Aickin C M, Burke C W

出版信息

Br Med J. 1975 Nov 22;4(5994):437-9. doi: 10.1136/bmj.4.5994.437.

DOI:10.1136/bmj.4.5994.437
PMID:811313
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1675395/
Abstract

Thyroid function and serum levels of triiodothyronine (T3) and thyroxine (T4) were investigated in 79 euthyroid geriatric patients. Of the 59 inpatients and 20 outpatients 35 (59%) and 2, respectively, had low T3 levels. In contrast, 7 (12%) and 6 (30%), respectively, had raised T4 levels. Two further patients were excluded from the study because of raised levels of thyroid-stimulating hormone. Thyroxine-binding globulin was greatly increased in both groups of patients, but low serum albumin levels were present in 31 (39%). Despite these changes free T3 and T4 indices closely followed total T3 and T4 levels. The difference between the two groups of patients did not correlate with body weight, diagnostic categories, age, drug treatment, or duration of stay in hospital.

摘要

对79例甲状腺功能正常的老年患者的甲状腺功能以及血清三碘甲状腺原氨酸(T3)和甲状腺素(T4)水平进行了研究。在59例住院患者和20例门诊患者中,分别有35例(59%)和2例T3水平较低。相比之下,分别有7例(12%)和6例(30%)T4水平升高。另有2例患者因促甲状腺激素水平升高而被排除在研究之外。两组患者的甲状腺素结合球蛋白均大幅升高,但31例(39%)患者血清白蛋白水平较低。尽管有这些变化,但游离T3和T4指数与总T3和T4水平密切相关。两组患者之间的差异与体重、诊断类别、年龄、药物治疗或住院时间无关。

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Thyroid hormones in the elderly sick: "T4 euthyroidism".老年患者中的甲状腺激素:“T4 正常甲状腺功能”
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引用本文的文献

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本文引用的文献

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Thyroxine turnover in euthyroid man with special reference to changes with age.正常甲状腺功能的男性体内甲状腺素的周转,特别提及随年龄的变化。
J Clin Invest. 1962 Nov;41(11):2065-74. doi: 10.1172/JCI104664.
2
The incidence of thyroglobulin antibodies and thyroid enlargement in a general practice in north-east England.英格兰东北部一家普通诊所中甲状腺球蛋白抗体和甲状腺肿大的发病率。
Clin Exp Immunol. 1966 Jul;1(3):277-84.
3
Free thyroxine in serum by equilibrium dialysis: effects of dilution, specific ions and inhibitors of binding.通过平衡透析法测定血清中的游离甲状腺素:稀释、特定离子及结合抑制剂的影响
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Thyrotropin response to thyrotropin releasing hormone in normal females over forty.
J Clin Endocrinol Metab. 1972 Jun;34(6):1096-8. doi: 10.1210/jcem-34-6-1096.
5
Response to thyrotropin releasing hormone (TRH) in normal man.正常男性对促甲状腺激素释放激素(TRH)的反应。
J Clin Endocrinol Metab. 1972 Feb;34(2):380-5. doi: 10.1210/jcem-34-2-380.
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Progressive decrease in serum triiodothyronine concentrations with human aging: radioimmunoassay following extraction of serum.血清三碘甲状腺原氨酸浓度随人类衰老而逐渐降低:血清提取后的放射免疫测定法
J Clin Endocrinol Metab. 1973 Aug;37(2):247-53. doi: 10.1210/jcem-37-2-247.
7
Observations concerning the binding of thyroid hormones in sera of normal subjects of varying ages.关于不同年龄正常受试者血清中甲状腺激素结合情况的观察
J Clin Invest. 1966 Aug;45(8):1273-9. doi: 10.1172/JCI105434.
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Effect of severe, chronic illness on thyroid function.严重慢性疾病对甲状腺功能的影响。
Lancet. 1974 Oct 26;2(7887):971-4. doi: 10.1016/s0140-6736(74)92070-4.
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Serum protein-bound and plasma in organic iodine in the elderly at home.居家老年人血清蛋白结合碘和血浆无机碘
Age Ageing. 1972 Aug;1(3):158-61. doi: 10.1093/ageing/1.3.158.
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Thyroid-function tests in the elderly.
Lancet. 1972 Apr 29;1(7757):924-7. doi: 10.1016/s0140-6736(72)91494-8.