Destrade C, Cardo B
C R Acad Hebd Seances Acad Sci D. 1975 Mar 17;280(11):1401-4.
In order to test the influence of a post-trial low level rewarding stimulation on learning, BALB/c mice were bilaterally implanted in the lateral hypothalamus. First, all the animals were submitted to a 15 mn appetitive learning session in a Skinner Box (CRF). 30 s later, animals of the experimental group were stimulated for 80 s (100 Hz sinusoidal current; 200 ms ON/200 ms OFF; 10 muA/electrode). 24 h later the performances of the stimulated animals were compared to those of non-stimulated or not implanted animals. An improvement of reminiscence effect was observed in stimulated animals. Second, the self-stimulation behavior was studied in stimulated subjects; at 10 muA, this behavior was effective in all animals. The results are interpreted as revealing the involvement of the rewarding system in memory processes.
为了测试试验后低水平奖励性刺激对学习的影响，将BALB/c小鼠双侧植入下丘脑外侧。首先，所有动物在斯金纳箱中进行15分钟的食欲学习训练（连续强化）。30秒后，对实验组动物进行80秒的刺激（100赫兹正弦电流；200毫秒开启/200毫秒关闭；每电极10微安）。24小时后，将受刺激动物的表现与未受刺激或未植入的动物进行比较。在受刺激动物中观察到记忆效应有所改善。其次，对受刺激的实验对象的自我刺激行为进行了研究；在10微安时，这种行为在所有动物中均有效。这些结果被解释为揭示了奖励系统参与了记忆过程。
