Galey D, Jeantet Y, Destrade C, Jaffard R
Behav Neural Biol. 1983 Jul;38(2):240-50. doi: 10.1016/s0163-1047(83)90240-6.
Sinusoidal (100 Hz) electrical stimulation was applied at a weak intensity (7.5 muA peak to peak) through bipolar electrodes located in the medial septal nucleus after partial acquisition of an appetitive operant conditioning task in a Skinner box. Analysis of performance in a retention test 24 hr later showed that (i) the presence of stimulation electrodes by itself impaired retention-test performance, and (ii) electrical stimulation applied 30 sec after the end of the acquisition session improves retention; this facilitatory effect disappeared when the treatment was delayed 15 min. Both impairment and facilitation were found to vary (considerably) among subjects. Electrodes located in the center of the medial septal nucleus led to both a greater impairment in unstimulated subjects and a greater facilitation in stimulated subjects than more anterior placements in the vicinity of the diagonal band. Finally, spectral analysis of hippocampal EEG showed that stimulation had no effect on rhythmic slow activity (RSA). These results are discussed in relation to studies showing that RSA is associated with memory-storage processes and our own hypothesis which underlines the importance of activation of septo-hippocampal cholinergic neurons in the early stages of these mnemonic processes.
在斯金纳箱中对一种食欲性操作条件反射任务进行部分习得后，通过位于内侧隔核的双极电极以弱强度（峰峰值7.5微安）施加正弦（100赫兹）电刺激。对24小时后进行的记忆测试中的表现分析表明：（i）刺激电极本身的存在会损害记忆测试表现；（ii）在习得阶段结束后30秒施加电刺激可改善记忆；当处理延迟15分钟时，这种促进作用消失。发现损害和促进作用在不同个体间（有很大）差异。与位于斜角带附近更靠前的位置相比，位于内侧隔核中心的电极在未受刺激的个体中导致更大的损害，在受刺激的个体中导致更大的促进作用。最后，海马脑电图的频谱分析表明，刺激对节律性慢活动（RSA）没有影响。结合表明RSA与记忆存储过程相关的研究以及我们自己强调在这些记忆过程早期激活隔-海马胆碱能神经元重要性的假说，对这些结果进行了讨论。
