Gauthier M, Destrade C, Soumireu-Mourat B
Brain Res. 1982 Feb 11;233(2):255-64. doi: 10.1016/0006-8993(82)91201-x.
Mice of the BALB/c strain were bilaterally implanted with electrodes in the lateral entorhinal cortex (EC) in order to study the influence of post-trial EC stimulation on memory. The learning task was a food reinforced operant conditioning. At one of several time intervals after a first learning session, the experimental groups were stimulated for 80 s with subseizure current intensity. Testing was carried out 24 h later. In the first experiment, a continuous reinforcement schedule was used. EC stimulation had no effect when applied at the 30-s or 3-h intervals, but surprisingly a 30-min delayed stimulation greatly improved retention compared to performance of non-stimulated animals. In the second experiment, the same paradigm was used in a discriminative operant conditioning task. The same facilitation on retention was observed only with the 30-min delayed stimulation. Compared to previous data with hippocampal or hypothalamic stimulation, the present results reveal that EC is lately involved in memory processes.
为了研究试验后内嗅皮层（EC）刺激对记忆的影响，在BALB/c品系小鼠的双侧内嗅皮层植入电极。学习任务是食物强化操作条件反射。在第一次学习训练后的几个时间间隔之一，以亚惊厥电流强度对实验组刺激80秒。24小时后进行测试。在第一个实验中，采用连续强化程序。在30秒或3小时的间隔施加EC刺激没有效果，但令人惊讶的是，与未受刺激的动物相比，延迟30分钟的刺激大大提高了记忆保持能力。在第二个实验中，相同的范式用于辨别操作条件反射任务。仅在延迟30分钟的刺激下观察到对记忆保持的相同促进作用。与先前海马或下丘脑刺激的数据相比，目前的结果表明内嗅皮层最近参与了记忆过程。
