Sodeyama T, Furuta S
Second Department of Internal Medicine, Shinshu University School of Medicine.
Nihon Rinsho. 1994 Jan;52(1):27-32.
The main etiological cause of liver cirrhosis that account for approximately 80% of liver cirrhosis in Japan in hepatitis virus, and HBV and HCV account for 38% and 59% of this hepatitis virus-induced liver cirrhosis, respectively. Liver cirrhosis develops in patients with persistent infection of HBV or HCV. A diminution in HBV replication can occur due to the immune response in cases with chronic hepatitis. In such cases, the liver disease may become almost normal or inactive after conversion to the nonreplicative phase. To the contrary, in some cases with HBV infection, such conversion does not occur leading finally to liver cirrhosis. Chronic infection takes place in 65% of the patients exposed to HCV, which results in the development of chronic hepatitis, and only quite rarely resolves. About 40% of these patients with chronic HCV infection will develop liver cirrhosis in 10 to 20 years.
在日本，导致肝硬化的主要病因是肝炎病毒，约占肝硬化病例的80%，其中乙肝病毒（HBV）和丙肝病毒（HCV）分别占这种由肝炎病毒引起的肝硬化的38%和59%。HBV或HCV持续感染的患者会发展为肝硬化。在慢性肝炎病例中，由于免疫反应，HBV复制可能会减少。在这种情况下，肝脏疾病在转变为非复制期后可能会几乎恢复正常或不再活跃。相反，在一些HBV感染病例中，这种转变不会发生，最终导致肝硬化。65%接触HCV的患者会发生慢性感染，这会导致慢性肝炎的发展，且很少自行痊愈。这些慢性HCV感染患者中约40%会在10至20年内发展为肝硬化。
