Korth M, Nguyen N X, Jünemann A, Martus P
DFG Klinische Forschergruppe Glaukome, Universität Erlangen-Nürnberg.
Klin Monbl Augenheilkd. 1993 Nov;203(5):324-8. doi: 10.1055/s-2008-1045685.
Glaucomatous eye diseases can be associated in many cases with a disturbance of blue-color vision. Also visual evoked potentials (VEPs) can be altered in glaucoma. In the present study both tests were combined in order to increase the sensitivity of the method, i.e. the pattern VEP was examined under conditions isolating the blue-sensitive part of the visual pathway.
34 normals, 14 patients with ocular hypertension (OHT), 15 patients with a so called pre-perimetric primary open-angle glaucoma (PPOAG), and 32 patients with primary open-angle glaucoma (POAG) were examined by presenting in the onset-offset mode blue stripe patterns 1. without an adaptive background light (blue- "black" pattern = BB) and 2. with an intensive yellow adaptation light (blue-on-yellow pattern = BY) suppressing the red- and green-sensitive cones. Amplitudes and peak times of the onset response were evaluated.
BB responses are of positive, BY responses of negative polarity (inion-ear). In normals the latter responses are significantly larger and have a significantly longer peak time. While in the patients groups the BB responses were not significantly altered, the BY responses were significantly reduced only in POAG. The peak time was significantly delayed in both PPOAGs and POAGs. The BY peak time proved to be most significant: Sensitivity 87.1%, specificity 82.4%.
The recording of the VEP with blue stimuli presented under selective yellow adaptation is a sensitive test for early glaucoma diagnosis.
在许多情况下，青光眼性眼病可能与蓝色视觉障碍有关。青光眼患者的视觉诱发电位（VEP）也可能发生改变。在本研究中，将这两种测试结合起来以提高该方法的敏感性，即在隔离视觉通路中蓝色敏感部分的条件下检查图形VEP。
对34名正常人、14名高眼压症（OHT）患者、15名所谓的视野前原发性开角型青光眼（PPOAG）患者和32名原发性开角型青光眼（POAG）患者进行检查，以起始-偏移模式呈现蓝色条纹图案：1. 无适应性背景光（蓝-“黑”图案=BB）；2. 有强烈的黄色适应光（蓝-黄图案=BY）以抑制红敏和绿敏视锥细胞。评估起始反应的振幅和峰值时间。
BB反应为正，BY反应为负极性（枕骨粗隆-耳垂）。在正常人中，后者的反应明显更大，峰值时间明显更长。在患者组中，BB反应没有明显改变，而BY反应仅在POAG中明显降低。PPOAG和POAG患者的峰值时间均明显延迟。BY峰值时间最为显著：敏感性87.1%，特异性82.4%。
在选择性黄色适应下记录蓝色刺激的VEP是早期青光眼诊断的一种敏感测试。
