青光眼患者蓝敏通路的视觉诱发电位测试

VEP test of the blue-sensitive pathway in glaucoma.

作者信息

Korth M, Nguyen N X, Jünemann A, Martus P, Jonas J B

机构信息

Department of Ophthalmology, University Erlangen-Nürnberg, Germany.

出版信息

Invest Ophthalmol Vis Sci. 1994 Apr;35(5):2599-610.

PMID:8163348

Abstract

PURPOSE

The blue-sensitive pathway in normal subjects and in patients with primary open-angle glaucoma (POAG) was tested with the pattern visual evoked potential (VEP) method under selective adaptation.

METHODS

Recording of pattern-onset VEP in response to blue (460-nm) stripes (0.88 c/deg) presented either without or with a bright yellow (570-nm) adaptation light (Maxwellian view, 33 degree diameter). Amplitude and peak times were evaluated, and the mean tritan score of the Farnsworth 100-hue test was determined. Age-matched normal subjects (n = 34) and (n = 32) patients with POAG were examined.

RESULTS

The amplitude and peak time of the VEP without selective adaptation did not discriminate normal subjects from the POAG group. With selective adaptation, the amplitude was reduced (P = 0.002) and its peak time delayed (P < 0.0001) in POAG, yielding a sensitivity of 75% and a specificity of 94%. The VEP measures only under selective adaptation correlated significantly in patients with POAG with the mean perimetric defect, with the optic disc damage, and with the 100-hue test.

CONCLUSIONS

Recording the blue-on-yellow VEP is a useful test in glaucoma research.

摘要

目的

采用图形视觉诱发电位（VEP）方法，在选择性适应条件下，对正常受试者和原发性开角型青光眼（POAG）患者的蓝敏通路进行检测。

方法

记录对蓝色（460纳米）条纹（0.88周/度）的图形起始VEP，条纹呈现时不使用或使用明亮的黄色（570纳米）适应光（麦克斯韦视野，直径33度）。评估振幅和峰值时间，并确定Farnsworth 100色调试验的平均蓝黄色觉异常评分。对年龄匹配的正常受试者（n = 34）和POAG患者（n = 32）进行检查。

结果

未进行选择性适应时，VEP的振幅和峰值时间无法区分正常受试者和POAG组。在选择性适应条件下，POAG患者的VEP振幅降低（P = 0.002），峰值时间延迟（P < 0.0001），敏感性为75%，特异性为94%。仅在选择性适应条件下的VEP测量值与POAG患者的平均视野缺损、视盘损害以及100色调试验显著相关。