Shirasu Y
Environ Qual Saf. 1975;4:226-31.
Our mutagenicity screening studies on pesticides totalling 165 have newly revealed microbial mutagenic activity in the following four compounds: 2,4-dinitrophenyl thiocyanate (NBT), sodium p-dimethylamino-azobenzene diazosulfonate (DAPA), 5-nitro-1-napthonitrile (NNN) and N-(1,1,2,2-tetrachloroethylthio)-4-cyclohexene-1, 2-dicarboximide (Captafol). Significance of mutagenicity testing on pesticides is discussed from the toxicological point of view. No definite relationship has been proven among mutagenicity, carcinogenicity and teratogenicity of pesticides although there are some correlations in these activities of several pesticides. Further studies are needed to clarify the significance of mutagenicity testing in toxicological areas.
我们对总共165种农药进行的致突变性筛选研究，新发现以下四种化合物具有微生物致突变活性：硫氰酸2,4-二硝基苯酯（NBT）、对二甲氨基偶氮苯重氮磺酸钠（DAPA）、5-硝基-1-萘腈（NNN）和N-（1,1,2,2-四氯乙硫基）-4-环己烯-1,2-二甲酰亚胺（克菌丹）。从毒理学角度讨论了农药致突变性测试的意义。尽管几种农药的这些活性之间存在一些相关性，但尚未证明农药的致突变性、致癌性和致畸性之间有明确的关系。需要进一步研究以阐明致突变性测试在毒理学领域的意义。
