Dunkel V C, Simmon V F
IARC Sci Publ. 1980(27):283-301.
Twenty-six chemicals treated in long-term carcinogenicity bioassays were tested for mutagenicity in the Salmonella/microsome plate assay. Of the eight chemical reported as being noncarcinogenic in animals, five were not mutagenic and three induced a mutagenic response. Thirteen chemicals were carcinogenic in either rats, mice or both species. Ten of these were positive in the mutagenicity assay, and three were negative. Four chemicals were suspect as far as the carcinogenicity results were concerned, and three were negative. The results obtained in vivo with one compound were inconclusive, and the mutagenicity results were negative.
对在长期致癌性生物测定中处理过的26种化学物质进行了沙门氏菌/微粒体平板试验中的致突变性测试。在报告对动物无致癌性的8种化学物质中，5种无致突变性，3种诱导出致突变反应。13种化学物质在大鼠、小鼠或两种物种中具有致癌性。其中10种在致突变性试验中呈阳性，3种呈阴性。就致癌性结果而言，4种化学物质存在疑问，3种呈阴性。一种化合物的体内实验结果尚无定论，致突变性结果为阴性。
