Bloom D S, Eidelman B H, McCalden T A
Gut. 1975 Sep;16(9):732-7. doi: 10.1136/gut.16.9.732.
The effects of intracarotid infusions of noradrenaline on the cerebral vasculature were studied in seven baboons with bile duct ligation. Infusion of 8 mug and 16 mug/min of noradrenaline resulted in a significant decrease in cerebral blood flow in the jaundiced animals. In normal baboons, these doses produced cerebrovascular dilatation. These results indicate that there is an increased cerebrovascular sensitivity to noradrenaline in the obstructive jaundice which follows bile duct ligation. It is postulated that noradrenaline smooth muscle uptake mechanisms are disturbed allowing a greater concentration of the amine at the receptor sites.
在七只胆管结扎的狒狒身上研究了颈内动脉注射去甲肾上腺素对脑血管系统的影响。以每分钟8微克和16微克的剂量注射去甲肾上腺素，可使黄疸动物的脑血流量显著减少。在正常狒狒中，这些剂量会引起脑血管扩张。这些结果表明，胆管结扎后发生的梗阻性黄疸中，脑血管对去甲肾上腺素的敏感性增加。据推测，去甲肾上腺素平滑肌摄取机制受到干扰，使得受体部位的胺浓度更高。
