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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Davis B A, Boulton A A

Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada.

Prog Neuropsychopharmacol Biol Psychiatry. 1994 Jan;18(1):17-45. doi: 10.1016/0278-5846(94)90022-1.

Investigations of the role of the trace amines (phenylethylamine, tryptamine, m- and p-tyramine) and their acidic metabolites (phenylacetic, indoleacetic, m- and p-hydroxyphenylacetic acids) in depression are reviewed. 2. The evidence for the phenylethylamine hypothesis of depression is mixed. 3. Reduced phenylacetic acid levels in urine, plasma and CSF and changes in those levels during treatment with antidepressants show potential as state markers for depression. 4. Impaired p-tyramine conjugation following a tyramine challenge may be a good trait marker for depression.

本文综述了痕量胺（苯乙胺、色胺、间酪氨酸和对酪氨酸）及其酸性代谢产物（苯乙酸、吲哚乙酸、间羟基苯乙酸和对羟基苯乙酸）在抑郁症中的作用研究。2. 抑郁症苯乙胺假说的证据存在矛盾。3. 尿液、血浆和脑脊液中苯乙酸水平降低以及抗抑郁药治疗期间这些水平的变化显示出作为抑郁症状态标志物的潜力。4. 酪胺激发后对酪氨酸结合受损可能是抑郁症的一个良好特质标志物。

Davis B A, Boulton A A

Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada.

Prog Neuropsychopharmacol Biol Psychiatry. 1994 Jan;18(1):17-45. doi: 10.1016/0278-5846(94)90022-1.

Investigations of the role of the trace amines (phenylethylamine, tryptamine, m- and p-tyramine) and their acidic metabolites (phenylacetic, indoleacetic, m- and p-hydroxyphenylacetic acids) in depression are reviewed. 2. The evidence for the phenylethylamine hypothesis of depression is mixed. 3. Reduced phenylacetic acid levels in urine, plasma and CSF and changes in those levels during treatment with antidepressants show potential as state markers for depression. 4. Impaired p-tyramine conjugation following a tyramine challenge may be a good trait marker for depression.

本文综述了痕量胺（苯乙胺、色胺、间酪氨酸和对酪氨酸）及其酸性代谢产物（苯乙酸、吲哚乙酸、间羟基苯乙酸和对羟基苯乙酸）在抑郁症中的作用研究。2. 抑郁症苯乙胺假说的证据存在矛盾。3. 尿液、血浆和脑脊液中苯乙酸水平降低以及抗抑郁药治疗期间这些水平的变化显示出作为抑郁症状态标志物的潜力。4. 酪胺激发后对酪氨酸结合受损可能是抑郁症的一个良好特质标志物。